Ƙaƙƙarfan ƙaƙƙarfan jigo mai ƙarfi na tsakiyar infrared (MIR) Laser a 6.45 um tare da matsakaicin matsakaicin ƙarfin fitarwa da ingancin katako na kusa da Gaussian an nuna shi. Matsakaicin ikon fitarwa na 1.53 W tare da bugun bugun jini na kusan 42 ns a 10 Ana samun kHz ta amfani da ZnGeP2 (ZGP) oscillator na gani na gani (OPO).Ana auna madaidaicin ƙimar ingancin katako don zama M2=1.19.
Haka kuma, high fitarwa ikon kwanciyar hankali da aka tabbatar, tare da wani ikon hawa da sauka na kasa da 1.35% rms kan 2 h, da kuma Laser iya gudu nagarta sosai fiye da 500 h a total. Amfani da wannan 6.45 um bugun jini a matsayin radiation Madogararsa, ablation na dabba. An gwada nama na kwakwalwa.Bugu da ƙari, ana yin nazarin tasirin lalacewa ta hanyar ka'ida a karon farko, gwargwadon iliminmu, kuma sakamakon ya nuna cewa wannan Laser na MIR yana da kyakkyawan ikon cirewa, yana mai da shi yuwuwar maye gurbin lasers na lantarki kyauta.©2022 Optica Publishing Group
Mid-infrared (MIR) 6.45 um Laser radiation yana da yuwuwar aikace-aikace a cikin manyan madaidaicin filayen magani saboda fa'idodinsa na ƙimar haɓakar haɓakawa da ƙarancin lalacewa. Raman Laser, da m-jihar Laser dangane da wani Tantancewar paramet-ric oscillator (OPO) ko bambancin mitar tsara (DFG) ana amfani da 6.45 um Laser kafofin. Duk da haka, da high cost, babban size, da kuma hadaddun tsarin na FELs ƙuntata su. Application.Strontium tururi Laser da gas Raman Laser iya samun manufa makada, amma duka biyu da matalauta kwanciyar hankali, short ser-
Nazarin ya nuna cewa 6.45 um m-state lasers samar da wani karami thermal dam-shekaru kewayon a cikin nazarin halittu kyallen takarda da kuma cewa su ablation zurfin ne zurfi fiye da na FEL a karkashin wannan yanayi, wanda ya tabbatar da cewa za su iya. za a yi amfani da matsayin tasiri madadin ga FELs ga nazarin halittu nama ablation 【2】. Bugu da kari, m-state Laser da abũbuwan amfãni daga wani m tsari, mai kyau kwanciyar hankali, da kuma
aikin tebur, yana sanya su kayan aikin alƙawarin don samun tushen hasken a6.45μn.Kamar yadda aka sani, lu'ulu'u na infrared marasa layi suna taka muhimmiyar rawa a cikin tsarin jujjuyawar mitar da ake amfani da su don cimma manyan ayyuka na MIR lasers. dace da samar da MIR Laser.Waɗannan lu'ulu'u sun haɗa da mafi yawan chalcogenides, irin su AgGaS2 (AGS), 3,41, LiInS2 (LIS), 5,61, LilnSe2 (LISe) 】】 da BaGaSe（BGse）【10-12】】】, da kuma phosphorus mahadi CdSiP2 (CSP) 【13-16】 da ZnGeP2 （ZGP）【17】； na karshen biyu duka suna da babban haɗin gwiwa na kan layi. Misali, MIR radiation za a iya samu ta amfani da CSP-OPOs. Duk da haka, mafi yawan CSP-OPOs aiki a kan wani ultrashort (pico-da femtosecond) lokaci sikelin kuma ana synchronously famfo da kamar 1 um yanayin-kulle lasers. Abin baƙin ciki, wadannan synchronously famfo OPO（ SPOPO) tsarin suna da tsarin saitin hadaddun kuma suna da tsada. Matsakaicin ƙarfin su kuma yana ƙasa da 100mW a kusa da 6.45 um [13-16]. Idan aka kwatanta da crystal CSP, ZGP yana da lalacewar Laser mafi girma ukushold (60MW/cm2) , mafi girma thermal conductiv-ity (0.36 W / cm K) , da kuma m maras kyau coefficient (75pm / V) .Saboda haka, ZGP ne m MIR mara kyau na gani crystal ga high-ikon ko high-ikon. makamashi aikace-aikace 【18-221.Misali, wani lebur-lebur rami ZGP-OPO tare da tuning kewayon 3.8-12.4 um famfo ta 2.93 um Laser aka nuna.Matsakaicin daya-pulse makamashi na rashin aiki haske a 6.6 um ya kasance. 1.2 mJ 【201. Domin ƙayyadaddun tsayin tsayi na 6.45 um, maxi-mum single-pulse energy na 5.67 mJ a maimaita mita na 100 Hz an samu ta amfani da rami na OPO wanda ba na tsari ba bisa ga crystal ZGP. Tare da maimaitawa. mitar 200Hz, matsakaicin ƙarfin fitarwa na 0.95 W ya kai 【221. Kamar yadda muka sani, wannan shine mafi girman ƙarfin fitarwa da aka samu a 6.45 um.Binciken da aka yi a baya ya nuna cewa matsakaicin matsakaicin matsakaici yana da mahimmanci don haɓakar ƙwayar nama mai tasiri 【23】.Saboda haka, haɓaka ingantaccen babban ƙarfin 6.45 um Laser tushen zai zama babban mahimmanci a cikin haɓaka maganin ilimin halitta.A cikin wannan Wasiƙar, muna ba da rahoton wani sauƙi, ƙarami mai ƙarfi duka-ƙarfi MIR 6.45 um Laser wanda ke da matsakaicin matsakaicin fitarwa kuma ya dogara ne akan ZGP-OPO wanda aka kunna ta nanosecond (ns) - bugun jini 2.09 um
Laser.Matsakaicin matsakaicin matsakaicin fitarwa na Laser 6.45 um har zuwa 1.53 W tare da nisa bugun jini na kusan 42ns a mitar maimaituwar 10 kHz, kuma yana da ingancin katako mai kyau.Tasirin ablating na 6.45 um Laser akan nama na dabba. Ana bincikar wannan aikin.Wannan aikin yana nuna cewa Laser hanya ce mai tasiri don ainihin zubar da ƙwayar tsoka, yayin da yake aiki a matsayin maƙalar laser.An zana saitin gwaji a cikin Fig.1.ZGP-OPO yana yin famfo ta hanyar gida na LD-pumped 2.09 um Ho: YAG Laser wanda ke ba da 28 W na matsakaicin iko a 10 kHz. tare da tsawon lokaci na bugun jini na kusan 102 ns ( FWHM) da matsakaicin nauyin ingancin katako na M2 na kusan 1.7.MI da M2 su ne madubai guda biyu na 45 tare da rufin da ke nunawa sosai a 2.09 um. Waɗannan madubai suna ba da damar sarrafa jagorancin famfo katako. Biyu mayar da hankali-ingancin ruwan tabarau （f1 = 100mm ,f2 = 100 mm) ana amfani da shi don haɗakar katako tare da diamita na katako na kusan 3.5 mm a cikin kristal ZGP. Ana amfani da mai keɓancewa na gani (ISO) don hana bututun famfo ya dawo zuwa tushen famfo 2.09 um. A farantin rabi mai raƙuman ruwa. (HWP) a 2.09 um da ake amfani da su sarrafa polarization na famfo haske.M3 da M4 ne OPO rami madubi, tare da lebur CaF2 amfani a matsayin substrate abu.The gaban madubi M3 ne anti-waiwaya mai rufi (98%) ga famfo. katako da kuma babban tunani mai rufi (98%) don 6.45 um idler da 3.09 um sigina tãguwar ruwa. The fitar-fita madubi M4 ne sosai m (98%) a 2.09um da 3.09 um kuma yana ba da damar watsa juzu'i na 6.45 um idler.An yanke ZGP crystal a 6-77.6 ° dap = 45 ° don nau'in-JⅡ lokaci daidaitawa 【2090.0 (o) 6450.0 (o) + 3091.9 layin layi idan aka kwatanta da nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in kifi) matching shine 5mmx6mm x 25mm gyarawa a cikin kwandon zafi na jan karfe tare da sanyaya ruwa (T = 16) . Tsawon rami shine 27 mm. Lokacin zagaye na OPO shine 0.537 ns don laser famfo. Mun gwada kofa na lalacewa na ZGP crystal ta R Hanyar -on-I 【17】.An auna iyakar lalacewar ZGP crystal don zama 0.11 J/cm2 a 10 kHz.a cikin gwaji, daidai da ƙarfin ƙarfin 1.4 MW / cm2, wanda yake ƙasa da ƙasa saboda in mun gwada da matalauta shafi ingancin.Ana auna ƙarfin fitarwa na hasken da aka ƙirƙira ta hanyar mita makamashi (D, OPHIR, 1 uW zuwa 3 W) kuma ana lura da tsawon tsawon hasken siginar ta hanyar sikirin (APE, 1.5-6.3 m) sami wani babban fitarwa ikon 6.45 um, mu inganta-mize da zane na sigogi na OPO.A lambobi kwaikwaiyo ne da za'ayi bisa uku-kalaman hadawa ka'idar da paraxial yaduwa cquations 【24,25】；a cikin kwaikwayo, mu yi amfani da sigogi masu dacewa da yanayin gwaji kuma ɗauka bugun bugun jini tare da bayanin martaba na Gaussian a sararin samaniya da lokaci.Dangantaka tsakanin madubin fitarwa na OPO
transmittance, famfo ikon tsanani, da kuma fitarwa yadda ya dace da aka gyara ta hanyar yin amfani da famfo katako yawa a cikin kogo don cimma mafi girma fitarwa ikon yayin da lokaci guda guje wa lalacewa ga ZGP crystal da Tantancewar abubuwa. Saboda haka, mafi girma famfo ikon da aka iyakance zuwa game da 20. W don aikin ZGP-OPO. Sakamakon da aka kwaikwayi ya nuna cewa ana amfani da madaidaicin fitarwa mai kyau tare da watsawa na 50%, matsakaicin matsakaicin ƙarfin ƙarfin shine kawai 2.6 x 10 W/cm2 a cikin ZGP crys-tal, da matsakaicin ƙarfin fitarwa. na fiye da 1.5 W za a iya samu.Hoto na 2 yana nuna dangantakar da ke tsakanin ma'auni na fitarwa na mai aiki a 6.45 um da kuma wutar lantarki da ya faru. Matsakaicin famfo kofa ya yi daidai da matsakaicin ƙarfin famfo na 3.55WA matsakaicin ƙarfin fitarwar rani na 1.53 W ana samunsa a ƙarfin famfo mai kusan 18.7 W, wanda yayi daidai da ingantaccen jujjuyawar gani-zuwa gani o of kusan 8.20%% da juzu'in juzu'in juzu'i na 25.31% Don aminci na dogon lokaci, ana sarrafa Laser a kusa da 70% na matsakaicin ikon fitar da shi. Ana auna kwanciyar hankali a ƙarfin fitarwa na IW, kamar yadda wanda aka nuna a cikin sa (a) a cikin Fig.2. An gano cewa canjin wutar lantarki da aka auna bai wuce 1.35% rms a cikin 2 h ba, kuma Laser na iya aiki da kyau fiye da 500 h a duka. Tsawon tsayin siginar sigina ana aunawa maimakon na mai zaman banza saboda iyakacin iyakar zangon sikirin (APE, 1.5-6.3 um) da aka yi amfani da shi a cikin gwajin mu. Tsawon siginar da aka auna yana tsakiya a 3.09 um kuma fadin layin yana kusan 0.3 nm, kamar yadda aka nuna. A inset (b) na Fig.2. Tsakanin tsayin raƙuman raɗaɗi sannan ana cire shi zuwa 6.45um. An gano nisa na bugun jini ta wurin mai binciken hoto (Thorlabs, PDAVJ10) kuma an rubuta shi ta hanyar oscilloscope na dijital (Tcktronix，2GHz) ）An nuna nau'in igiyar oscilloscope na yau da kullun a cikin Fig.3 kuma yana nuna nisa bugun bugun jini kusan 42 ns. Faɗin bugun bugun jiniyana da 41.18% kunkuntar don 6.45 um idler idan aka kwatanta da 2.09 um famfo bugun jini saboda sakamakon sakamako na wucin gadi na tsarin jujjuyawar mitar da ba ta dace ba. 6.45 um idler ana auna shi tare da katako na Laser
analyzer (Spiricon, M2-200-PIII) a 1 W na fitarwa ikon, kamar yadda aka nuna a cikin Fig.4.The auna dabi'u na M2 da M, 2 ne 1.32 da 1.06 tare da x axis da y axis, bi da bi, daidai da Matsakaicin matsakaici na M2 = 1.19. Hannun Fifial na Fiv.4 yana nuna yanayin girman hoto (2D) na kusa da shi. Ana yin gwajin ƙa'idodin ƙa'ida wanda ya haɗa da cirewar laser na kwakwalwar porcine. An yi amfani da ruwan tabarau f=50 don mai da hankali kan ƙwanƙwasa bugun jini na 6.45 zuwa radius ɗin kugu na kusan 0.75 mm. Matsayin da za a soke a kan nama na kwakwalwar porcine. an sanya shi a mayar da hankali na katako na Laser. Yanayin zafin jiki (T) na kwayoyin halitta a matsayin aiki na wuri na radial r yana da ma'auni ta hanyar thermocamera (FLIR A615) tare da daidaitawa yayin aikin ablation. Tsawon lokacin rani shine 1. , 2,4,6,10, da 20 s a Laser ikon I W. Ga kowane lokacin sakawa a iska mai guba, shida samfurin matsayi suna blated: r=0,0.62,0.703,1.91,3.05, da 4.14 mm tare da radial shugabanci game da tsakiyar batu na sakawa a iska mai guba, kamar yadda aka nuna a cikin Fig.5.The murabba'ai ne auna yawan zafin jiki data.An samu a cikin Fig.5 cewa surface zafin jiki. a matsayi na ablation a kan nama yana ƙaruwa tare da ƙara tsawon lokacin iska mai iska.Mafi girman lokaci-peratures T a tsakiyar tsakiya r = 0 shine 132.39,160.32,196.34.
205.57,206.95, da 226.05C don iska mai guba durations na 1,2,4,6,10, da kuma 20 s, bi da bi.Don nazarin da m lalacewa, da yawan zafin jiki rarraba a kan ablated nama surface da aka kwaikwaya.Wannan ne da za'ayi bisa ga the thermal conduction theory for bioological tissue
Ana yin simintin ɗin tare da zato na shigar da katako na Gaussian. Tun da naman halittun da aka yi amfani da shi a cikin gwajin ya keɓanta nama na kwakwalwar porcine, ba a kula da tasirin jini da metabolism akan zafin jiki, kuma ana sauƙaƙa nama na kwakwalwar porcine cikin siffar silinda don simula-tion.Ma'auni da aka yi amfani da su a cikin simintin an taƙaita su a cikin Table 1. Ƙwararrun maɗaukaki da aka nuna a cikin Fig.5 sune rarrabawar zafin jiki na radial da aka kwatanta game da cibiyar ablation a kan nama na nama na shida daban-daban irradiation. durations.Suna nuna yanayin zafin jiki na Gaussian daga tsakiya zuwa gefe. Ya bayyana daga Fig.5 cewa bayanan gwaji sun yi kyau tare da sakamakon da aka kwatanta. Matsayin ablation yana ƙaruwa yayin da tsawon lokacin irradia-tion ya karu ga kowane irradiation.Bincike na baya ya nuna cewa sel a cikin nama suna da lafiya sosai a lokacin da ke ƙasa.55C, wanda ke nufin cewa sel suna aiki a cikin koren yankuna (T <55C) na masu lanƙwasa a cikin Fig.5. Yankin rawaya na kowane kwana (55C)60C) .Za a iya lura a cikin Fig.5 cewa simulated ablation radii a T = 60 ° Care0.774,0.873,0.993,1.071,1.198 da 1.364 mm, bi da bi, don irradiation durations na 1,2,4,6, 10, da 20s, yayin da simulated ablation radii atT = 55C ne0.805,0.908,1.037,1.134,1.271, da 1.456 mm, bi da bi. Bayan da yawa nazarin ablation sakamako, da Arca tare da matattu Kwayoyin da aka samu su zama, 1.882. 2.394,3.098,3.604,4.509, da 5.845 mm2 don 1,2,4,6,10, da 20s na sakawa a iska mai guba, bi da bi.Yankin da ke da lalacewar lalacewa an samo shi ne 0.003,0.0040.006,0.017,0.0. da kuma 0.027 mm2. Ana iya ganin cewa sassan ablation na laser da yankunan lalacewa na lalacewa sun karu tare da tsawon lokaci na irradiation.Mun ayyana ma'auni na lalacewa don zama rabo na yanki na lalacewa a 55C s T60C. ya zama 8.17%, 8.18%, 9.06%, 12.11%, 12.56%, da 13.94% na lokuta daban-daban na irradiation, wanda ke nufin cewa lalacewar kyallen takarda ba ta da yawa. Saboda haka, cikakken gwajil bayanai da sakamakon kwaikwaya sun nuna cewa wannan ƙaramin ƙarfi, babban iko, duk-ƙarfin-jihar 6.45 um ZGP-OPO Laser yana ba da ingantaccen zubar da kyallen jikin halitta. MIR pulsed 6.45 um Laser tushen bisa tsarin ns ZGP-OPO. An sami matsakaicin matsakaicin matsakaicin ƙarfin 1.53 W tare da ƙarfin kololuwar 3.65kW da matsakaicin ƙimar ingancin katako na M2=1.19.Yin amfani da wannan 6.45 um MIR radiation,a An yi gwajin gwaji na ƙa'ida akan Laser ablation na nama.An auna rarraba zafin jiki akan farfajiyar nama da aka zubar da shi ta hanyar gwaji da kuma simu-lated.Bayanan da aka ƙididdige sun yarda da kyau tare da sakamakon da aka kwaikwaya.Bugu da ƙari, an yi la'akari da lalacewa ta hanyar ka'ida. A karo na farko.Wadannan sakamakon tabbatar da cewa mu tabletop MIR bugun jini Laser a 6.45 um yana ba da tasiri ablation na nazarin halittu Tissucs kuma yana da babban damar zama wani m kayan aiki a likita da ilmin halitta kimiyya, kamar yadda zai iya maye gurbin wani m FEL kamar yadda.Laser fatar kan mutum.